Aya Othman was last seen on Sunday night at about 10.30pm in the Woodhouse area.
The teen is described as as being 5ft 2in tall with a slim build.
She was last seen wearing an orange dress and tights.
Police are appealing to anyone with information to contact them on 101 quoting log 1879.
A West Yorkshire Police spokesperson said “#missing. Have you seen Aya Othman. 15 year old female missing from Woodhouse area of Leeds.
“Call police on 101 quoting log 1879 with any information.”